An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase
Barrios-Camacho et al. develop an in vitro model of nascent horizontal basal cells (HBCs) activation. Transcriptomic profiling of HBCs at various stages of activation reveals discrete gene regulatory networks also seen in the in vivo injury context. Despite initiating activation gene signatures, HBCs can regress and re-establish dormancy markers. Further, activated HBCs differ in engraftment and differentiation responses when transplanted.
Barrios-Camacho et al. develop an in vitro model of nascent horizontal basal cells (HBCs) activation. Transcriptomic profiling of HBCs at various stages of activation reveals discrete gene regulatory networks also seen in the in vivo injury context. Despite initiating activation gene signatures, HBCs can regress and re-establish dormancy markers. Further, activated HBCs differ in engraftment and differentiation responses when transplanted.
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